| Region | 02 of 6 confirmed |
| Type | Tropical archipelago |
| Inspiration | The Florida Keys |
| Story role | Jason's world at the start; the first safehouse |
"A tropical archipelago where life stays easy and the water gets deadly." — after Rockstar's official description
The Leonida Keys are the island chain trailing off the southern tip of Leonida — GTA 6's take on the Florida Keys. Rockstar's description sets the contrast that defines the region: the dress code is casual, the bars stay loaded, and just offshore lie some of the most beautiful and dangerous waters in America.
The Keys are protagonist Jason Duval's world at the beginning of the game — he works for veteran smuggler Brian Heder out of a local boat yard, and Jason and Lucia's first safehouse sits in the islands. Confirmed Keys characters include Brian Heder, his wife Lori, and Jason's friend Cal Hampton.
Rockstar's character bios tie the region's identity to its history: Brian Heder is described as a runner from the golden age of smuggling in the Keys — a place where product has always moved by water.